Protein Homology Detection Through Alignment of Markov by Jinbo Xu,Sheng Wang,Jianzhu Ma

By Jinbo Xu,Sheng Wang,Jianzhu Ma

This paintings covers sequence-based protein homology detection, a primary and tough bioinformatics challenge with quite a few real-world purposes. The textual content first surveys a couple of renowned homology detection tools, akin to Position-Specific Scoring Matrix (PSSM) and Hidden Markov version (HMM) established tools, after which describes a unique Markov Random Fields (MRF) established process constructed through the authors. MRF-based tools are even more delicate than HMM- and PSSM-based equipment for distant homolog detection and fold reputation, as MRFs can version long-range residue-residue interplay. The textual content additionally describes the install, utilization and end result interpretation of courses imposing the MRF-based method.

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